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- Vin Diesel as Xander Cage
- Asia Argento as Yelena
- Samuel L. Jackson as Agent Augustus Gibbons
- Marton Csokas as Yorgi
- Michael Roof as Toby Lee Shavers
- Richy Muller as Milan Sova
- Werner Daehn as Kirill
- Petr Jakl as Kolya
- Tom Everett as Senator Dick Hotchkiss
- Danny Trejo as El Jefe
- Thomas Ian Griffith as Agent Jim McGrath
- Eve as J.J.
- Leila Arcieri as Jordan King
- William Hope as Agent Roger Donnan